IGURATIMOD ALLEVIATES MYOCARDIAL ISCHEMIA/REPERFUSION INJURY THROUGH INHIBITING INFLAMMATORY RESPONSE INDUCED BY CARDIAC FIBROBLAST PYROPTOSIS VIA COX2/NLRP3 SIGNALING PATHWAY

Background: NLRP3 inflammasome contributes a lot to sterile inflammatory response and pyroptosis in ischemia/reperfusion (I/R) injury.Cardiac fibroblasts (CFs) are regarded as semi-professional inflammatory cells and they exert an immunomodulatory role in heart.Iguratimod provides a protective role in several human diseases through exerting a power

Ginger is a culinary spice with a millennia-old tradition due to its extensive therapeutic applications, recently validated by scientific studies.In particular [6]-Gingerol, a key active molecule in ginger, exhibits extraordinary capabilities in addressing a wide spectrum of health issues.However, its therapeutic potential is limited by its rather

Aim.Current clinical recommendations accentuate current methods for the diagnosis and treatment of irritable bowel syndrome (IBS).Key points.IBS is a functional bowel disorder manifested with recurrent, at least weekly, abdominal pain with the following attributes (any two leastwise): link to defecation, its frequency or stool shape.The symptoms ar